Fc receptor mediated inhibitory signaling pathway

Across TCGA patient cohorts, RNA activity of the Fc receptor mediated inhibitory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB2, KLHL6, and LILRB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fc receptor mediated inhibitory signaling pathway activity versus LILRB2 in HNSC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LILRB2 →	+0.690	+0.572	<.001	<.001	3	7
GBM	KLHL6 →	+0.714	+0.253	<.001	<.001	3	7
BRCA	LILRB1 →	+0.779	+0.660	<.001	<.001	3	6
CCRCC	JAK3 →	+0.761	+0.613	<.001	.001	3	6
HNSC	BTN3A3 →	+0.642	+0.677	.002	.001	3	6
GBM	THEMIS2 →	+0.902	+0.280	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002774 vs LILRB2 — HNSC

Explore this scatter interactively →