Fc receptor mediated inhibitory signaling pathway

Across TCGA cell cohorts, RNA activity of the Fc receptor mediated inhibitory signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOS1, ARHGAP23, and AAMP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOS1 grouped by Fc receptor mediated inhibitory signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SOS1 →	+0.405	+0.774	.001	<.001	3	4
LUNG_SCLC	ARHGAP23 →	-0.168	-1.565	.003	.008	2	5
LUNG_NSCLC_LUAD	AAMP →	+0.368	+0.896	<.001	.002	3	4
BREAST	CSF1 →	+0.123	+1.022	.005	.006	3	4
BLOOD_Myeloma	TBCE →	-0.294	-0.306	.004	.004	3	3
BLOOD_Lymphoma	MAP3K1 →	-0.316	-0.597	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOS1 by Fc receptor mediated inhibitory signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →