Immune response-inhibiting cell surface receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Immune response-inhibiting cell surface receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM179B, PHF12, and FOXRED1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune response-inhibiting cell surface receptor signaling pathway activity versus TMEM179B in BLOOD_Leukemia (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM179B →	+0.427	+1.085	.004	.002	3	2
BLOOD_Leukemia	PHF12 →	+0.417	+0.863	.001	.002	3	1
BLOOD_Leukemia	FOXRED1 →	+0.371	+0.894	.006	.001	3	1
BLOOD_Leukemia	CRYZ →	+1.025	+0.934	.002	<.001	3	1
BLOOD_Leukemia	SASH3 →	+2.146	+0.983	.008	.001	3	1
BLOOD_Leukemia	ARMC7 →	+0.452	+0.854	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002767 vs TMEM179B — BLOOD_Leukemia

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