Immune response-inhibiting signal transduction

Across TCGA patient cohorts, RNA activity of the Immune response-inhibiting signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD53, CD48, and CCL5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune response-inhibiting signal transduction activity versus CD53 in GBM (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD53 →	+0.967	+0.298	<.001	<.001	3	8
GBM	CD48 →	+0.901	+0.415	<.001	<.001	3	7
COAD	CCL5 →	+1.268	+0.576	<.001	.002	3	7
GBM	NCF4 →	+0.859	+0.292	<.001	<.001	3	7
BRCA	NKG7 →	+1.198	+0.368	<.001	<.001	3	7
GBM	PLEK →	+0.913	+0.266	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002765 vs CD53 — GBM

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