Immune response-inhibiting signal transduction

Across TCGA cell cohorts, RNA activity of the Immune response-inhibiting signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD5, EED, and TBX3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune response-inhibiting signal transduction activity versus ABHD5 in BLOOD_Myeloma (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ABHD5 →	+1.770	+1.879	<.001	.008	1	3
BLOOD_Leukemia	EED →	+0.670	+0.901	.002	.002	3	1
BLOOD_Leukemia	TBX3 →	-1.004	-0.726	<.001	.002	3	1
BLOOD_Leukemia	MTHFS →	+0.935	+0.772	.003	.007	3	1
BLOOD_Leukemia	GBP4 →	+1.644	+0.652	.004	.007	3	1
BLOOD_Leukemia	RAMAC →	+0.414	+0.817	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002765 vs ABHD5 — BLOOD_Myeloma

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