Positive regulation of myeloid leukocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, EGR2, and GIMAP6, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte differentiation activity versus CSF2RB in CHOL (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	CSF2RB →	+1.771	+0.060	<.001	<.001	3	33
LAML	EGR2 →	+1.770	+0.044	<.001	<.001	3	33
SCLC	GIMAP6 →	+1.561	+0.095	<.001	<.001	3	33
DLBC	P2RY13 →	+2.132	+0.066	<.001	.004	3	33
SCLC	CCR4 →	+1.301	+0.093	<.001	<.001	3	33
ACC	CSF1 →	+1.799	+0.031	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002763 vs CSF2RB — CHOL

Explore this scatter interactively →