Positive regulation of myeloid leukocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR65, IL21R, and CCR5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte differentiation activity versus GPR65 in LSCC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPR65 →	+0.516	+0.186	.002	.001	3	7
UCEC	IL21R →	+0.933	+0.237	<.001	.003	3	6
PDAC	CCR5 →	+0.497	+0.161	<.001	<.001	3	6
LSCC	CXCL13 →	+1.449	+0.224	.003	<.001	3	6
HNSC	CRTAM →	+0.498	+0.133	.009	.009	3	5
LSCC	CD48 →	+0.891	+0.284	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002763 vs GPR65 — LSCC

Explore this scatter interactively →