Positive regulation of myeloid leukocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid leukocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCLT1_S656, BIN2, and CORO1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte differentiation activity versus SCLT1_S656 in LSCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SCLT1_S656 →	+0.558	+0.249	<.001	<.001	3	4
LSCC	BIN2 →	+0.605	+0.287	<.001	<.001	3	4
LSCC	CORO1A →	+0.617	+0.297	<.001	<.001	3	4
LSCC	MYO1G →	+0.589	+0.299	<.001	<.001	3	4
LSCC	STK10 →	+0.434	+0.277	<.001	<.001	3	4
UCEC	FERMT3 →	+0.508	+0.225	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002763 vs SCLT1_S656 — LSCC

Explore this scatter interactively →