Positive regulation of myeloid leukocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myeloid leukocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENC1, MYO7A, and LMO2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENC1 grouped by Positive regulation of myeloid leukocyte differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ENC1 →	+0.400	+0.822	<.001	<.001	3	6
LUNG_NSCLC_LUSC	MYO7A →	+0.191	+0.269	.008	.003	3	5
SKIN	LMO2 →	-0.128	-0.510	.003	.009	3	5
SOFT_TISSUE	OR2H1 →	-0.355	-1.696	.008	.001	3	5
KIDNEY	KCNK9 →	-0.194	-1.352	.002	<.001	3	4
SKIN	NONO →	+0.206	+0.763	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENC1 by Positive regulation of myeloid leukocyte differentiation activity — SKIN

Explore this box plot interactively →