Positive regulation of myeloid leukocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BPNT2, BAG4, and PLEK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BPNT2 grouped by Positive regulation of myeloid leukocyte differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BPNT2 →	+0.927	+0.416	<.001	.002	3	5
BLOOD_Lymphoma	BAG4 →	+1.370	+2.106	<.001	<.001	3	4
CNS	PLEK →	+0.102	+0.699	.002	.002	3	4
STOMACH	NECAB2 →	+0.587	+0.248	.004	<.001	3	4
STOMACH	MRAS →	+2.431	+0.277	.009	<.001	3	4
STOMACH	RTL5 →	+1.776	+0.280	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BPNT2 by Positive regulation of myeloid leukocyte differentiation activity — URINARY_TRACT

Explore this box plot interactively →