Positive regulation of myeloid leukocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIF, CAPN2, and SDC4, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte differentiation activity versus LIF in SKIN (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LIF →	+2.882	+0.153	<.001	<.001	3	14
LIVER	CAPN2 →	+2.845	+0.125	.001	<.001	2	13
SOFT_TISSUE	SDC4 →	+3.189	+0.093	<.001	.002	3	12
LIVER	LGALS1 →	+4.363	+0.135	<.001	<.001	3	12
BONE	RUNX1 →	+2.131	+0.081	.007	.004	3	12
LIVER	THBS1 →	+4.951	+0.151	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002763 vs LIF — SKIN

Explore this scatter interactively →