Regulation of myeloid leukocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of myeloid leukocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARPC1B, STAB1, and TBC1D2B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myeloid leukocyte differentiation activity versus ARPC1B in GBM (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARPC1B →	+0.654	+0.066	<.001	<.001	3	10
GBM	STAB1 →	+0.659	+0.065	<.001	<.001	3	10
GBM	TBC1D2B →	+0.440	+0.071	<.001	<.001	3	10
OV	WIPF1 →	+0.507	+0.040	<.001	<.001	3	10
OV	ZYX_S143 →	+1.534	+0.049	.001	<.001	3	10
GBM	DPYD →	+0.825	+0.051	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002761 vs ARPC1B — GBM

Explore this scatter interactively →