Positive regulation of antimicrobial humoral response

Across TCGA patient cohorts, RNA activity of the Positive regulation of antimicrobial humoral response pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KLK7, UNC13D, and SERPINB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of antimicrobial humoral response activity versus KLK7 in UCEC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLK7 →	+2.132	+1.643	<.001	<.001	3	6
GBM	UNC13D →	+0.723	+1.073	<.001	<.001	3	6
HNSC	SERPINB1 →	+0.742	+0.386	<.001	<.001	3	5
GBM	LRRFIP1 →	+0.381	+0.779	<.001	<.001	3	5
GBM	SPEN →	-0.219	-0.693	<.001	.001	3	5
GBM	SPIN1 →	-0.415	-1.075	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002760 vs KLK7 — UCEC

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