MyD88-independent toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the MyD88-independent toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUFY4, PKIA, and PTPN22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, MyD88-independent toll-like receptor signaling pathway activity versus RUFY4 in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RUFY4 →	+0.452	+0.824	<.001	<.001	3	5
UCEC	PKIA →	+0.803	+0.661	.002	.008	3	4
LSCC	PTPN22 →	+0.613	+0.605	<.001	<.001	3	4
LSCC	P2RY13 →	+0.673	+0.684	<.001	<.001	3	4
HNSC	SLC8A1 →	+0.562	+0.502	.004	.006	2	5
LUAD	MNDA →	+0.503	+0.679	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002756 vs RUFY4 — LUAD

Explore this scatter interactively →