MyD88-independent toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the MyD88-independent toll-like receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGBD3, TBL1X, and FEM1A, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGBD3 grouped by MyD88-independent toll-like receptor signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PGBD3 →	+0.286	+0.499	<.001	.001	3	2
SKIN	TBL1X →	-0.267	-0.373	.001	.001	3	2
SKIN	FEM1A →	-0.202	-0.435	.002	.007	3	2
SKIN	SLC47A1 →	-0.187	-0.390	<.001	<.001	3	2
SKIN	POLR2H →	+0.260	+0.450	.003	.003	3	2
SKIN	NELL1 →	-0.216	-0.517	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGBD3 by MyD88-independent toll-like receptor signaling pathway activity — SKIN

Explore this box plot interactively →