MyD88-independent toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the MyD88-independent toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECD, ASCC1, and SPTLC3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, MyD88-independent toll-like receptor signaling pathway activity versus ECD in SKIN (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ECD →	+0.472	+0.301	.003	.004	3	3
SKIN	ASCC1 →	+0.468	+0.352	.001	.001	3	3
SOFT_TISSUE	SPTLC3 →	-3.027	-0.241	.001	.001	3	3
CNS	TRDMT1 →	-0.970	-0.371	.001	.003	3	2
CNS	NCAM1 →	-3.829	-0.462	.004	.003	3	2
CNS	WDR92 →	+0.343	+0.345	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002756 vs ECD — SKIN

Explore this scatter interactively →