MyD88-dependent toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the MyD88-dependent toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGLV2-23, KLHL6, and IGHJ6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, MyD88-dependent toll-like receptor signaling pathway activity versus IGLV2-23 in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGLV2-23 →	+2.397	+0.586	.003	.006	3	5
UCEC	KLHL6 →	+0.750	+0.644	.007	.002	3	5
UCEC	IGHJ6 →	+1.398	+0.407	.002	.005	3	5
GBM	PIK3CG →	+0.856	+0.496	<.001	.005	3	5
GBM	LY9 →	+0.206	+0.443	<.001	.009	3	5
OV	IGKV1-9 →	+2.032	+0.623	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002755 vs IGLV2-23 — OV

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