MyD88-dependent toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the MyD88-dependent toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GAT3, UXS1, and EXTL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, MyD88-dependent toll-like receptor signaling pathway activity versus B3GAT3 in BONE (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	B3GAT3 →	-1.152	-0.183	.007	.004	3	4
LUNG_SCLC	UXS1 →	+0.565	+0.159	.005	.003	3	4
LUNG_SCLC	EXTL3 →	-1.258	-0.127	<.001	.009	3	4
BLOOD_Lymphoma	ARRB2 →	-1.085	-0.225	.006	.003	3	4
BLOOD_Lymphoma	CCDC28B →	-1.540	-0.211	.008	.001	3	4
BLOOD_Myeloma	RNF149 →	+1.811	+0.308	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002755 vs B3GAT3 — BONE

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