Cell surface pattern recognition receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Cell surface pattern recognition receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3, WAS, and BTK, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell surface pattern recognition receptor signaling pathway activity versus SASH3 in HNSC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SASH3 →	+0.535	+0.057	<.001	.003	3	10
GBM	WAS →	+0.531	+0.062	<.001	<.001	3	10
LSCC	BTK →	+0.492	+0.081	<.001	<.001	3	10
LSCC	ADPRH →	+0.343	+0.065	<.001	<.001	3	10
GBM	AIF1 →	+0.696	+0.072	<.001	<.001	3	10
GBM	FYB1 →	+0.563	+0.062	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002752 vs SASH3 — HNSC

Explore this scatter interactively →