Cell surface pattern recognition receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Cell surface pattern recognition receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A14, EPPK1, and LIX1L, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell surface pattern recognition receptor signaling pathway activity versus S100A14 in URINARY_TRACT (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	S100A14 →	+6.288	+1.664	<.001	<.001	3	9
URINARY_TRACT	EPPK1 →	+2.344	+1.736	.001	<.001	3	8
STOMACH	LIX1L →	-2.837	-1.590	.001	<.001	3	7
SOFT_TISSUE	CORO2B →	-3.194	-0.533	.003	.001	2	7
BREAST	FSD1L →	-1.130	-1.357	<.001	<.001	3	6
OESOPHAGUS	OSTM1 →	-1.535	-1.514	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002752 vs S100A14 — URINARY_TRACT

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