Positive regulation of dendritic cell cytokine production

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYNC2I2, PLCG2, and ITSN2, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic cell cytokine production activity versus DYNC2I2 in TGCT (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	DYNC2I2 →	-0.778	-0.057	<.001	<.001	3	21
ACC	PLCG2 →	+1.152	+0.061	<.001	<.001	3	21
THYM	ITSN2 →	+0.700	+0.061	.001	<.001	3	21
LAML	MIR7848 →	+1.078	+0.093	<.001	<.001	3	20
THYM	EDF1 →	-0.517	-0.041	<.001	<.001	3	19
THYM	SSNA1 →	-0.432	-0.036	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002732 vs DYNC2I2 — TGCT

Explore this scatter interactively →