Positive regulation of dendritic cell cytokine production

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic cell cytokine production pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCG2, ADA2, and LCP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic cell cytokine production activity versus PLCG2 in UCEC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLCG2 →	+0.727	+0.082	<.001	<.001	3	9
UCEC	ADA2 →	+0.641	+0.059	<.001	.004	3	9
GBM	LCP1 →	+0.745	+0.083	<.001	<.001	3	9
GBM	MYO1F →	+0.640	+0.095	<.001	<.001	3	9
UCEC	ARHGAP25 →	+0.618	+0.065	<.001	.001	3	9
GBM	ARHGAP30 →	+0.644	+0.078	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002732 vs PLCG2 — UCEC

Explore this scatter interactively →