Positive regulation of dendritic cell cytokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RACK1, ABLIM2, and LSM14B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RACK1 grouped by Positive regulation of dendritic cell cytokine production-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RACK1 →	+1.604	+0.362	<.001	.001	3	4
LUNG_SCLC	ABLIM2 →	-2.670	-0.311	<.001	.003	3	4
OESOPHAGUS	LSM14B →	-1.126	-0.385	<.001	<.001	3	4
BREAST	FADS2 →	-2.359	-0.280	.003	<.001	3	3
BREAST	INSIG1 →	-0.902	-0.176	.001	.007	3	3
BREAST	LENG9 →	+0.679	+0.261	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RACK1 by Positive regulation of dendritic cell cytokine production activity — LUNG_SCLC

Explore this box plot interactively →