Positive regulation of dendritic cell cytokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCG2, SLC35A5, and SAMD9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic cell cytokine production activity versus PLCG2 in URINARY_TRACT (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PLCG2 →	-2.926	-0.355	.003	.001	3	6
LUNG_NSCLC_LUAD	SLC35A5 →	-0.591	-0.168	.002	.004	3	6
LARGE_INTESTINE	SAMD9 →	-1.777	-0.152	.002	.003	3	5
SKIN	CTSS →	-2.102	-0.137	.001	.002	3	5
OVARY	AFAP1L2 →	-2.514	-0.106	.001	.002	3	4
BONE	RPS21 →	+1.054	+0.282	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002732 vs PLCG2 — URINARY_TRACT

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