Positive regulation of T cell cytokine production

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell cytokine production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, TBXAS1, and THEMIS2_T593, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell cytokine production activity versus SKAP2 in GBM (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SKAP2 →	+0.692	+0.086	<.001	<.001	3	10
GBM	TBXAS1 →	+0.497	+0.084	<.001	<.001	3	10
BRCA	THEMIS2_T593 →	+0.864	+0.039	<.001	<.001	3	10
GBM	WAS →	+0.590	+0.100	<.001	<.001	3	10
GBM	CORO1A →	+0.572	+0.109	<.001	<.001	3	10
GBM	DEF6 →	+0.571	+0.096	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002726 vs SKAP2 — GBM

Explore this scatter interactively →