Positive regulation of T cell cytokine production

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KMO, KLHL6, and HLA-F, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell cytokine production activity versus KMO in UCEC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KMO →	+0.813	+0.817	.002	.001	3	5
UCEC	KLHL6 →	+0.679	+0.690	.007	.004	3	5
HNSC	HLA-F →	+0.734	+0.434	.003	.003	3	5
HNSC	CXCL11 →	+1.482	+0.530	.003	<.001	3	5
LSCC	TMEM150B →	+0.571	+0.584	.003	.002	3	5
LUAD	GZMA →	+0.712	+0.356	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002726 vs KMO — UCEC

Explore this scatter interactively →