Positive regulation of T cell cytokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF837, TMEM182, and SUSD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF837 grouped by Positive regulation of T cell cytokine production-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZNF837 →	+0.499	+1.079	<.001	.006	3	4
OVARY	TMEM182 →	+1.057	+1.153	<.001	.003	3	4
CNS	SUSD2 →	-1.366	-0.756	.003	.006	3	4
BLOOD_Leukemia	HADHB →	+0.839	+1.133	.007	.003	3	4
OVARY	NECTIN3 →	-1.373	-1.145	.004	.001	3	4
STOMACH	CYCS →	+1.073	+1.777	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF837 by Positive regulation of T cell cytokine production activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →