Positive regulation of T cell cytokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell cytokine production pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF26A, LIPG, and OR7C2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF26A grouped by Positive regulation of T cell cytokine production-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KIF26A →	-0.157	-0.329	<.001	.004	3	4
PANCREAS	LIPG →	+0.123	+0.362	<.001	.002	3	4
BREAST	OR7C2 →	+0.248	+1.679	<.001	<.001	3	4
BREAST	FOXA1 →	-0.739	-1.849	<.001	<.001	3	4
OESOPHAGUS	LPGAT1 →	+0.095	+0.250	.006	.006	3	4
PANCREAS	SETD6 →	-0.145	-0.423	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF26A by Positive regulation of T cell cytokine production activity — PANCREAS

Explore this box plot interactively →