Negative regulation of cytokine production involved in immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytokine production involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARID1A, BAG4, and DDI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARID1A grouped by Negative regulation of cytokine production involved in immune response-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ARID1A →	-0.521	-1.076	.007	.001	3	4
BREAST	BAG4 →	+0.851	+0.826	.004	.005	3	4
BREAST	DDI2 →	+0.526	+0.692	<.001	.005	3	4
SKIN	ZMAT3 →	+1.099	+0.807	.001	.003	3	4
PANCREAS	ZBTB48 →	-0.727	-1.526	.004	<.001	2	5
KIDNEY	DDB2 →	+0.812	+0.905	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARID1A by Negative regulation of cytokine production involved in immune response activity — OESOPHAGUS

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