Positive regulation of natural killer cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Positive regulation of natural killer cell mediated immunity pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT85, SH2D3C, and TEC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KRT85 grouped by Positive regulation of natural killer cell mediated immunity-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KRT85 →	-0.322	-0.173	.001	.009	3	5
OVARY	SH2D3C →	+0.162	+0.107	.004	.001	3	4
LARGE_INTESTINE	TEC →	+0.205	+0.191	.003	<.001	3	4
BONE	PRDM4 →	+0.318	+0.210	.007	.001	3	4
LIVER	PALB2 →	-0.319	-0.253	.009	.002	3	4
BONE	ZFX →	-0.463	-0.184	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRT85 by Positive regulation of natural killer cell mediated immunity activity — BLOOD_Myeloma

Explore this box plot interactively →