Negative regulation of natural killer cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of natural killer cell mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RENBP, COTL1, and DOCK10, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of natural killer cell mediated immunity activity versus RENBP in HNSC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RENBP →	+0.482	+0.113	<.001	<.001	3	10
LSCC	COTL1 →	+0.553	+0.096	<.001	<.001	3	10
LSCC	DOCK10 →	+0.514	+0.096	<.001	<.001	3	10
GBM	AIF1 →	+0.832	+0.105	<.001	<.001	3	10
OV	FERMT3 →	+0.547	+0.053	.001	<.001	3	10
GBM	ABI3 →	+0.511	+0.098	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002716 vs RENBP — HNSC

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