Negative regulation of natural killer cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of natural killer cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTN3A3, TAP2, and HLA-F, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of natural killer cell mediated immunity activity versus BTN3A3 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BTN3A3 →	+1.036	+0.264	<.001	<.001	3	7
BRCA	TAP2 →	+1.056	+0.247	<.001	<.001	3	7
COAD	HLA-F →	+0.845	+0.240	.007	.001	3	7
BRCA	ZBP1 →	+1.156	+0.210	<.001	.001	3	6
LSCC	SP110 →	+0.678	+0.332	<.001	<.001	3	6
BRCA	VAV1 →	+0.849	+0.196	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002716 vs BTN3A3 — BRCA

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