Negative regulation of natural killer cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Negative regulation of natural killer cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACC1, OSBPL5, and SASH3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TACC1 grouped by Negative regulation of natural killer cell mediated immunity-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TACC1 →	-1.309	-0.902	<.001	<.001	3	4
CNS	OSBPL5 →	-0.594	-0.789	.003	.009	3	4
LIVER	SASH3 →	+0.126	+1.390	.003	.004	3	3
LIVER	DCTD →	+0.986	+1.509	<.001	<.001	3	3
LIVER	ZNF736 →	-1.650	-1.126	.004	.004	3	3
SKIN	CDKN1A →	+2.677	+1.289	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TACC1 by Negative regulation of natural killer cell mediated immunity activity — BREAST

Explore this box plot interactively →