Negative regulation of natural killer cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Negative regulation of natural killer cell mediated immunity pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM3, SIX3, and TRIM74, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TPM3 grouped by Negative regulation of natural killer cell mediated immunity-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TPM3 →	-0.362	-0.253	.005	.001	3	5
BONE	SIX3 →	-0.394	-0.191	.002	.002	3	5
BLOOD_Myeloma	TRIM74 →	+0.173	+0.145	.001	<.001	3	4
PANCREAS	RMND5A →	+0.173	+0.112	.003	.001	3	4
LUNG_SCLC	C2CD5 →	-0.311	-0.268	.006	.006	3	4
URINARY_TRACT	BCAR1 →	+0.308	+0.231	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TPM3 by Negative regulation of natural killer cell mediated immunity activity — BONE

Explore this box plot interactively →