Negative regulation of natural killer cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Negative regulation of natural killer cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELL2, TUBB2A, and ITGB3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of natural killer cell mediated immunity activity versus ELL2 in BONE (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ELL2 →	+3.079	+0.439	<.001	<.001	3	7
LARGE_INTESTINE	TUBB2A →	+1.838	+0.233	<.001	.001	3	6
BONE	ITGB3 →	+3.006	+0.358	.003	.003	3	6
BONE	SLC7A8 →	-3.293	-0.425	<.001	<.001	3	6
SKIN	CCN1 →	+2.560	+0.197	.007	.006	3	5
OVARY	AXL →	+3.203	+0.518	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002716 vs ELL2 — BONE

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