Regulation of natural killer cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of natural killer cell mediated immunity pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, BCLAF1, and ELAVL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Regulation of natural killer cell mediated immunity-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TEAD1 →	+0.396	+0.560	.002	<.001	3	5
LUNG_NSCLC_LUAD	BCLAF1 →	-0.174	-0.184	.009	.003	3	5
BONE	ELAVL2 →	-0.330	-0.549	<.001	.003	2	5
STOMACH	EP400 →	-0.502	-0.392	.008	.001	3	4
LUNG_NSCLC_LUSC	TRRAP →	-0.620	-0.592	.002	.004	2	5
BREAST	ATP8A2 →	-0.179	-0.301	.003	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Regulation of natural killer cell mediated immunity activity — OVARY

Explore this box plot interactively →