Positive regulation of B cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Positive regulation of B cell mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARD9_S460, APOBR, and PARVG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell mediated immunity activity versus CARD9_S460 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CARD9_S460 →	+0.661	+0.024	.002	.002	3	8
GBM	APOBR →	+0.453	+0.044	<.001	<.001	3	8
GBM	PARVG →	+0.632	+0.052	<.001	<.001	3	8
GBM	DPYD →	+0.554	+0.035	<.001	<.001	3	8
BRCA	MYO1F_S1023 →	+0.737	+0.025	<.001	.002	3	8
GBM	PTPN6 →	+0.566	+0.048	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002714 vs CARD9_S460 — BRCA

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