Positive regulation of B cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Positive regulation of B cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXM1, ASPM, and NEK2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell mediated immunity activity versus FOXM1 in LUAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FOXM1 →	+0.899	+0.205	<.001	<.001	3	7
BRCA	ASPM →	+0.885	+0.559	<.001	<.001	3	7
BRCA	NEK2 →	+0.926	+0.708	<.001	<.001	3	6
BRCA	SGO1 →	+0.672	+1.100	<.001	<.001	3	6
LUAD	CCDC150 →	+0.574	+0.226	<.001	<.001	3	6
LUAD	SGO2 →	+0.684	+0.216	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002714 vs FOXM1 — LUAD

Explore this scatter interactively →