Positive regulation of B cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Positive regulation of B cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIGD7, ZNF281, and TANC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell mediated immunity activity versus TIGD7 in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TIGD7 →	+0.699	+0.200	.007	<.001	3	6
OVARY	ZNF281 →	+0.674	+0.179	.001	.003	3	5
BLOOD_Leukemia	TANC1 →	+1.790	+0.192	.004	.003	3	4
LARGE_INTESTINE	LAMB2 →	+0.880	+0.168	.005	.005	3	4
STOMACH	ATP5F1D →	-1.388	-0.385	<.001	<.001	3	4
BLOOD_Leukemia	SERINC3 →	+0.632	+0.162	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002714 vs TIGD7 — LUNG_NSCLC_LUAD

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