Regulation of B cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of B cell mediated immunity pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHEK1, ZNF777, and CFHR3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHEK1 grouped by Regulation of B cell mediated immunity-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CHEK1 →	-0.305	-0.228	.003	.004	3	4
LUNG_NSCLC_LUAD	ZNF777 →	+0.180	+0.285	.001	.003	3	4
PANCREAS	CFHR3 →	-0.363	-0.334	<.001	<.001	3	4
SOFT_TISSUE	TERF1 →	-0.353	-0.503	.002	.005	3	4
SKIN	HLTF →	-0.117	-0.234	.006	.007	3	3
LUNG_NSCLC_LUAD	SLC5A5 →	-0.118	-0.250	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHEK1 by Regulation of B cell mediated immunity activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →