Regulation of B cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of B cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA6C, E2F6, and SPDYE5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell mediated immunity activity versus SEMA6C in OVARY (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SEMA6C →	+1.111	+0.182	<.001	.001	3	6
PANCREAS	E2F6 →	+0.735	+0.314	.007	.001	3	6
LARGE_INTESTINE	SPDYE5 →	+0.465	+0.319	.002	<.001	3	4
LIVER	HYI →	-2.409	-0.248	.003	.002	3	4
STOMACH	SP5 →	-1.950	-0.311	.003	.007	2	5
LIVER	PRAG1 →	-1.535	-0.208	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002712 vs SEMA6C — OVARY

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