Positive regulation of T cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFNG, GPR174, and SLAMF6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell mediated immunity activity versus IFNG in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IFNG →	+1.290	+0.269	<.001	<.001	3	9
COAD	GPR174 →	+0.902	+0.158	<.001	<.001	3	9
LSCC	SLAMF6 →	+1.142	+0.260	<.001	<.001	3	9
OV	TFEC →	+1.075	+0.141	<.001	.001	3	8
GBM	CD2 →	+1.093	+0.188	.001	.003	3	8
HNSC	ZBP1 →	+1.175	+0.346	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002711 vs IFNG — LSCC

Explore this scatter interactively →