Negative regulation of T cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1_S351, RGS19, and SAMSN1_S107, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell mediated immunity activity versus RCSD1_S351 in LSCC (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1_S351 →	+0.646	+0.078	<.001	<.001	3	10
OV	RGS19 →	+0.456	+0.054	<.001	<.001	3	10
LSCC	SAMSN1_S107 →	+0.815	+0.103	<.001	<.001	3	10
BRCA	SAMSN1_S23 →	+0.996	+0.075	<.001	<.001	3	10
GBM	SASH3 →	+0.548	+0.097	<.001	<.001	3	10
LSCC	SERPINB9 →	+0.576	+0.102	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002710 vs RCSD1_S351 — LSCC

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