Negative regulation of T cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLA2, UBASH3A, and IKZF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell mediated immunity activity versus SLA2 in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLA2 →	+0.714	+0.279	<.001	<.001	3	10
CCRCC	UBASH3A →	+0.959	+0.531	<.001	<.001	3	10
UCEC	IKZF1 →	+0.821	+0.332	<.001	<.001	3	10
CCRCC	ARRDC5 →	+0.654	+0.439	<.001	.001	3	10
GBM	CCL4 →	+1.282	+0.253	.001	<.001	3	10
HNSC	LCP2 →	+0.853	+0.303	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002710 vs SLA2 — HNSC

Explore this scatter interactively →