Negative regulation of T cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYO1F, SKAP2, and SPN_S355, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell mediated immunity activity versus MYO1F in UCEC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO1F →	+0.556	+0.357	<.001	<.001	3	10
GBM	SKAP2 →	+0.632	+0.303	<.001	<.001	3	9
LSCC	SPN_S355 →	+0.780	+0.410	<.001	<.001	3	9
UCEC	STX11 →	+0.655	+0.419	<.001	<.001	3	9
GBM	VAV1 →	+0.682	+0.451	<.001	<.001	3	9
GBM	WAS →	+0.504	+0.259	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002710 vs MYO1F — UCEC

Explore this scatter interactively →