Regulation of T cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Regulation of T cell mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and RGS19, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell mediated immunity activity versus RCSD1 in GBM (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.584	+0.075	<.001	<.001	3	10
BRCA	RCSD1_S351 →	+0.657	+0.038	<.001	<.001	3	10
COAD	RGS19 →	+0.487	+0.032	.001	<.001	3	10
GBM	SAMSN1_S107 →	+0.910	+0.094	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.863	+0.073	<.001	<.001	3	10
OV	SASH3 →	+0.568	+0.044	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002709 vs RCSD1 — GBM

Explore this scatter interactively →