Regulation of T cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of T cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MASTL, HEATR3, and ZMAT3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MASTL grouped by Regulation of T cell mediated immunity-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MASTL →	+0.997	+1.007	.001	<.001	3	3
BREAST	HEATR3 →	+0.501	+0.616	.005	.002	3	3
BREAST	ZMAT3 →	+0.697	+0.542	<.001	.007	3	3
BREAST	ST7L →	+0.768	+0.825	<.001	.001	3	3
LUNG_NSCLC_LUSC	WEE1 →	-1.048	-1.405	.007	.009	3	3
LUNG_SCLC	SMARCA1 →	+2.449	+0.721	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MASTL by Regulation of T cell mediated immunity activity — BREAST

Explore this box plot interactively →