Regulation of T cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of T cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PA2G4, CHERP, and MCM2, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell mediated immunity activity versus PA2G4 in BONE (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PA2G4 →	-0.933	-0.088	.002	<.001	3	17
SKIN	CHERP →	-0.827	-0.071	<.001	.003	3	14
PANCREAS	MCM2 →	-1.530	-0.098	<.001	<.001	3	14
SOFT_TISSUE	NCL →	-0.810	-0.097	<.001	<.001	3	14
SOFT_TISSUE	POLR1B →	-0.799	-0.089	<.001	<.001	3	14
BONE	URB2 →	-1.253	-0.071	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002709 vs PA2G4 — BONE

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