Positive regulation of lymphocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Positive regulation of lymphocyte mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THEMIS2, PTPN6, and CCDC88B_S597, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lymphocyte mediated immunity activity versus THEMIS2 in OV (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THEMIS2 →	+0.545	+0.020	.006	.004	3	10
GBM	PTPN6 →	+0.510	+0.042	<.001	<.001	3	10
GBM	CCDC88B_S597 →	+0.778	+0.052	<.001	<.001	3	10
CCRCC	HCLS1 →	+0.582	+0.044	<.001	<.001	3	10
BRCA	SAMSN1_S23 →	+0.964	+0.018	<.001	.002	3	9
BRCA	CYBB →	+1.002	+0.025	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002708 vs THEMIS2 — OV

Explore this scatter interactively →