Positive regulation of lymphocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Positive regulation of lymphocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APPL2, SOX4, and FASTKD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APPL2 grouped by Positive regulation of lymphocyte mediated immunity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	APPL2 →	-0.511	-0.716	<.001	.001	3	4
STOMACH	SOX4 →	-2.905	-1.287	<.001	.004	3	4
KIDNEY	FASTKD2 →	+0.576	+1.182	<.001	<.001	3	4
CNS	MMP24 →	-1.149	-0.930	.004	<.001	3	3
CNS	DNALI1 →	-1.902	-0.861	.001	.007	3	3
CNS	TMEM130 →	-0.884	-0.650	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APPL2 by Positive regulation of lymphocyte mediated immunity activity — SKIN

Explore this box plot interactively →